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Description Information about methadone

Methadone Binds to opiate receptors in the central nervous system. Alters perception and response to painful stimuli, producing generalized CNS depression. Therapeutic effects: Decreased severity of pain. Suppression of withdrawal symptoms during detoxification and maintenance from heroin and other opioids .

INDICATIONS AND USE
1. For the treatment of moderate to severe pain that does not respond to non-narcotic analgesics.
2. For the detoxification treatment of opioid addiction (heroin or other morphine-like drugs).
3. For the maintenance treatment of opioid addiction (heroin or other morphine-like drugs), in combination with

adequate social and health services.

Acute Pain – Patients on a stable dose of methadone who are experiencing physical trauma, postoperative
pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients
should be given analgesics, including opioids, in doses that would otherwise be indicated for non-methadone patients with similar pain conditions. Because of methadone-induced opioid tolerance, when opioids are required for acute pain management in methadone patients, somewhat higher and/or more frequent doses will often be required than would be necessary for non-tolerant patients.

CONTRAINDICATIONS

Methadone is contraindicated in patients with known hypersensitivity to methadone hydrochloride or any other
ingredient in DOLOPHINE.
Methadone is contraindicated in any situation where opioids are contraindicated such as patients with respiratory
depression (in the absence of resuscitation equipment or in unmonitored settings) and in patients with acute
bronchial asthma or hypercapnia.
Methadone is contraindicated in all patients who have or are suspected of having paralytic ileus.

Methadone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus
. Pediatric Use Safety and efficacy in pediatric patients younger than 18 years have not been established. The major risks of methadone are respiratory depression and, to a lesser extent, systemic hypotension.
Respiratory arrest, shock, cardiac arrest, and death have occurred.

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