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Buy Oxycodone 60mg Sandoz , Buy Oxycodone online HERE from best online medicine store. Oxycodone Opioid Meds is the best online medicine store to order Oxycodone online. However, Oxycodone is a semi-synthetic opioid synthesized from the baine, an opioid alkaloid found in the Persian poppy and one of several alkaloids found in the opium poppy. It is a moderately potent opioid pain medication (orally about 1.5 times more potent than morphine), usually indicated for the relief of moderate to severe pain. Oxycodone is a pure opioid agonist whose primary therapeutic action is analgesia. Other members of the class known as opioid agonists include substances such as morphine, hydromorphone, fentanyl, codeine, and hydrocodone. The pharmacological effects of opioid agonists include anxiolysis, euphoria, a feeling of relaxation, respiratory depression, constipation, miosis, and cough suppression, as well as analgesia. Like all pure opioid agonist analgesics. In conclusion, order oxycodone online to relieve your moderate to severe pain. A 215 imprint A 215 is blue, round, and also supplied by Actavis. used in the treatment of chronic pain; pain and belongs to the class of narcotic analgesics.

Registered indications:  Treatment of severe pain.

Active ingredient : oxycodone hydrochloride .
Pharmacological properties
Oxycodone is a semi-synthetic opioid structurally related to morphine and codeine; like morphine, it has a high affinity for the mu, kappa and delta receptors of the brain and spinal cord and has no antagonistic properties.
Administered orally, it is well absorbed. The release of oxycodone from the tablets occurs in two phases, with a relatively rapid initial release that produces an early onset of the analgesic effect, followed by a more controlled release that determines a duration of action of 12 hours1. Maximum plasma concentrations are reached after approximately 3 hours2. At the hepatic level, oxycodone is metabolised by cytochrome P450 to noroxycodone and to a lesser extent to oxymorphone which do not contribute to its analgesic effect and which are eliminated in the urine3. The half-life is 4-5 hours. In the elderly, oxycodone clearance is only slightly reduced and does not require dosage adjustment.

Adverse reactions
Adverse reactions of controlled-release oxycodone are the same as those of oral morphine in incidence and type and include constipation, nausea and/or vomiting (25-30% of patients), sedation, dizziness and pruritus. Adverse reactions are typical of strong opioids and, except for constipation (which can be treated with appropriate laxatives), tend to decrease over time.

Warnings Oxycontin
tablets should be swallowed whole and should not be crushed or chewed. This warning appears particularly important since taking broken tablets results in a rapid release of the active ingredient and the absorption of a potentially lethal dose of oxycodone2,3.

Interactions
Like all opioids, oxycodone potentiates the central depressant effects of phenothiazines, tricyclic antidepressants, hypnotics, sedatives and alcohol. The metabolism of oxycodone may be reduced by cimetidine and other cytochrome P450 inhibitors such as azole antifungals (eg ketoconazole) and macrolides ( especially erythromycin ). Conversely, P450 inhibitors such as quinidine may increase the plasma concentrations and half-life of the drug2.

Dosage:  10 mg every 12 hours, to be increased, with increments of 25-50%, until the pain is controlled. In patients with severe renal or hepatic insufficiency, it is necessary to reduce the dosage or the frequency of administrations.